Genetic Background Predicts Poor Prognosis in Frontotemporal Lobar Degeneration
نویسندگان
چکیده
منابع مشابه
Genetic background predicts poor prognosis in frontotemporal lobar degeneration.
BACKGROUND Ruling out predictors of survival in frontotemporal lobar degeneration (FTLD) is a clinical challenge for defining disease outcomes and monitoring therapeutic interventions. Little is known about determinants of survival in FTLD. OBJECTIVE The aim of the present study was to identify whether genetic determinants are key, not only as risk factors but as predictors of survival in FTL...
متن کامل[Frontotemporal lobar degeneration].
Article abstract-Objectiue: To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. Methods: Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed by members of an international workshop on frontotemporal lo...
متن کاملUnpicking frontotemporal lobar degeneration.
Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006; 314: 130–3. Piguet O, Hornberger M, Shelley BP, Kipps CM, Hodges JR. Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia. Neurology 2009; 72: 732–7. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensit...
متن کاملFrontotemporal Lobar Degeneration
Frontotemporal lobar degeneration (FTLD) comprises diseases with a very diverging spectrum in regards to clinical presentation, genetics, and neuropathology. In 1892 Arnold Pick published the case of 71-year old male with progressive symptoms of aphasia, apathy, and dementia (Pick 1892). The pathological examination revealed cortical atrophy with emphasis on the left temporal lobe (Pick 1892). ...
متن کاملBiomarkers in frontotemporal lobar degeneration.
PURPOSE OF REVIEW Recent findings assessing the utility of neuroimaging and biofluid biomarkers are reviewed that help identify patients with frontotemporal lobar degeneration (FTLD) spectrum abnormality. RECENT FINDINGS Neuroimaging studies using T1 structural MRI and diffusion tensor imaging (DTI) distinguish between patients with FTLD and Alzheimer's disease, although the reliability of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurodegenerative Diseases
سال: 2011
ISSN: 1660-2862,1660-2854
DOI: 10.1159/000322790